Masayuki Akimoto

AKIMOTO Masayuki

Professor

area of expertise: biopharmaceuticals, drug metabolism

Research theme/keyword

Metabolism of anti-inflammatory drugs, drug-drug interactions Research on product evaluation of generic drugs

Major achievements

1.Hori S., Kawata T., Kogure S., Yabu S., Mori K., and Akimoto M.*, Comparative release studies on suppositories using the basket, paddle, dialysis tubing and flow-through cell methods I. Acetaminophen in a lipophilic base suppository. Pharm Dev Technol. 2017 Feb;22(1):130-135.
2.Mori K., Hori S., Kawata T., Kogure S., Matsumoto k., Hasegawa T., Akimoto M.*, The in Vitro Release of Indomethacin from Suppositories: Effects of Bases and Comparison of Different Dissolution Methods. Chem Pharm Bull., 2017;65(7):674-677
3.Matsumoto K., Hasegawa T., Ohara K., Takei C., Akimoto M.*, Roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in the metabolism of 6-methoxy-2-napthylacetic acid J. Pharm. Investig., 50, 71-79 (2020).
4.Matsumoto K., Hasegawa T., Ohara K., Takei C., Kamei T., Koyanagi J., Takahashi T., Akimoto M.*, A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6- methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. Xenobiotica 50, 783-792 (2020).
5.Matsumoto K., Hasegawa T., Ohara K., Kamei T., Koyanagi J., Akimoto M*., Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the Activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. Xenobiotica 51, 155-166 (2021).
6. Shibata Y., Ohara K., Matsumoto K., Hasegawa T., Akimoto M.*, Total Anthocyanin Content, Total Phenolic Content, and Antioxidant Activity of Various Blueberry Cultivars Grown in Togane, Chiba, Japan. J. Nutr Sci. Vitaminol. 67, 201-209 (2021).

Click here for detailed research results

Social contribution activities

・ Chiba prefecture 6 university collaboration meeting: member
・ Chiba Prefecture 3 Universities “Pharmacist Training Program Contributing to the Establishment and Development of Practical Social Pharmacy”: Business Manager
・General Incorporated Foundation Chiba Pharmacist Association Inspection Center: Councilor

message

"Continuity is power" It is important to move forward little by little. However, if you have any doubts, you need to stop and think and ask for help. Do not lose interest.