Issei Takeuchi

Research theme/keyword

Research on formulation design for efficient drug delivery

Major achievements

1) I. Takeuchi*, Y. Kimura, T. Nakajima, K. Makino*, “Effects of lower alcohols on nanocomposite particles for inhalation prepared using O/W emulsion”, Bio-Medical Materials and Engineering, 33 (2022), 159-168.
2) K. Yoshikawa, T. Nii, K. Troev, K. Makino, I. Takeuchi*, “Poly(alkyloxyethylene-lactate phosphate) for delivery of doxorubicin: synthesis and characterization”, Anticancer Research, 42 (2022), 1801 -1811.
3) I. Takeuchi*, K. Tanaka, K. Makino, “Therapeutic effects of GGsTop® gel in a mouse model of 5-fluorouracil-induced oral mucositis with reduced white blood cells”, Anticancer Research, 41 (2021) 4313- 4319.
4) I. Takeuchi*, Y. Kato, K. Makino, “Effects of polyvinyl alcohol on drug release from nanocomposite particles using poly(L-lactide-co-glycolide)”, Journal of Oleo Science, 70 (2021) 341- 348.
5) I. Takeuchi, R. Kawamata, K. Makino, “Effects of GGsTop® on collagen and glutathione in the oral mucosa using a rat model of 5-fluorouracil-induced oral mucositis”, in vivo, 35 (2021) 175- 180.
6) I. Takeuchi*, T. Suzuki, K. Makino, “Iontophoretic transdermal delivery using chitosan-coated PLGA nanoparticles for transcutaneous immunization”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 608 (2021) 125607.
7) I. Takeuchi*, A. Kagawa, K. Makino, “Skin permeability and transdermal delivery route of 30-nm cyclosporin A-loaded nanoparticles using PLGA-PEG-PLGA triblock copolymer”, Colloids and Surfaces A: Physicochemical and Engineering Aspects , 600 (2020) 124866.
8) I. Takeuchi, Y. Kimura, K. Makino, “Effects of the conformation of poly(L-lactide-co-glycolide) molecules in organic solvents on nanoparticle size”, Journal of Oleo Science, 69 (2020) 1125- 1132.
9) I. Takeuchi, R. Kawamata, K. Makino, “A rat model for oral mucositis induced by cancer chemotherapy for quantitative experiments”, Anticancer Research, 40 (2020) 2401-2406.
10) I. Takeuchi, Y. Koshi, K. Makino, “Drug delivery properties of nanocomposite particles for inhalation: comparison of drug concentrations in lungs and blood”, in vivo, 34 (2020) 543-547.
11) I. Takeuchi, C. Togo, K. Makino, “Rebamipide-containing film using chitosan and HPMC for oral mucositis induced by cancer chemotherapy”, Anticancer Research, 39 (2019) 6531-6536.
12) I. Takeuchi, Y. Kanno, H. Uchiro, K. Makino, “Polyborane-encapsulated PEGylated liposomes prepared using post-insertion technique for boron neutron capture therapy”, Journal of Oleo Science, 68 (2019) 1261-1270.
13) I. Takeuchi, K. Makino, “Biocompatibility and effectiveness of paclitaxel-encapsulated micelle using phosphoester compounds as a carrier for cancer treatment”, Colloids and Surfaces B: Biointerfaces, 177 (2019) 356-361.
14) Y. Kakami, I. Takeuchi, K. Makino, “Percutaneous immunization with 40-nm antigen-encapsulated elastic liposomes”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 566 (2019) 128-133.
15) I. Takeuchi, M. Ariyama, K. Makino, “Chitosan coating effect on cellular uptake of PLGA nanoparticles for boron neutron capture therapy”, Journal of Oleo Science, 68 (2019) 361-368.
16) I. Takeuchi, Y. Shimamura, Y. Kakami, T. Kameda, K. Hattori, S. Miura, H. Shirai, M. Okumura, T. Inagi, H. Terada, K. Makino, “Transdermal delivery of 40-nm silk fibroin nanoparticles”, Colloids and Surfaces B: Biointerfaces, 175 (2019) 564-568.
17) Y. Shimamura, I. Takeuchi, H. Terada, K. Makino, “Therapeutic effect of GGsTop, selective gamma-glutamyl transpeptidase inhibitor, on a mouse model of 5-fluorouracil-induced oral mucositis”, Anticancer Research, 39 ( 2019) 201-206.
18) T. Nakajima, I. Takeuchi, H. Ohshima, H. Terada, K. Makino, “Push-pull controlled drug-release systems: Effect of molecular weight of polyethylene oxide on drug-release”, Journal of Pharmaceutical Sciences, 107 (2018) 1896-1902.
19) I. Takeuchi, Y. Kamiki, K. Makino, “Therapeutic efficacy of rebamipide-loaded PLGA nanoparticles coated with chitosan in a mouse model for oral mucositis induced by cancer chemotherapy”, Colloids and Surfaces B: Biointerfaces, 167 (2018) 468-473.
20) I. Takeuchi, N. Kishi, K. Shiokawa, H. Uchiro, K. Makino, “Polyborane encapsulated liposomes prepared using pH gradient and reverse phase evaporation for boron neutron capture therapy: biodistribution in tumor-bearing mice”, Colloid and Polymer Science, 296 (2018) 1137-1144.
21) I. Takeuchi, R. Mikuni, K. Makino, “Synthesis of phosphoester compounds using lactic acid for encapsulation of paclitaxel”, Anticancer Research, 38 (2018) 3401-3406.
22) I. Takeuchi, M. Otuski, H. Kuroda K., Makino, “Estimation of crystallinity of indomethacin by usage of terahertz time-domain spectroscopy and calibration curve: correlation between crystallinity and solubility”, Journal of Drug Delivery Science and Technology. , 45 (2018) 70-75.
23) I. Takeuchi, Y. Hida, K. Makino, “Minoxidil-encapsulated poly(L-lactide-co-glycolide) nanoparticles with hair follicle delivery properties prepared using W/O/W solvent evaporation and sonication”, Bio-Medical Materials and Engineering, 29 (2018) 217-228.
24) I. Takeuchi, H. Onaka, K. Makino, “Biodistribution of colloidal gold nanoparticles after intravenous injection: Effects of PEGylation at the same particle size”, Bio-Medical Materials and Engineering, 29 (2018) 205-215.
25) T. Nii, I. Takeuchi, Y. Kimura, K. Makino, “Effects of the conformation of PLGA molecules in the organic solvent on the aerodynamic diameter of spray dried microparticles”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 539 (2018) 347-353.
26) I. Takeuchi, Y. Taniguchi, Y. Tamura, K. Ochiai, K. Makino, “Effects of L-leucine on PLGA microparticles for pulmonary administration prepared using spray drying: fine particle fraction and phagocytotic ratio of alveolar macrophages”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 537 (2018) 411-417.
27) Y. Shimamura, I. Takeuchi, H. Terada, K. Makino, “A mouse model for oral mucositis induced by cancer chemotherapy”, Anticancer Research, 38 (2018) 307-312.
28) I. Takeuchi, T. Takeshita, T. Suzuki, K. Makino, “Iontophoretic transdermal delivery using chitosan-coated PLGA nanoparticles for positively charged drugs”, Colloids and Surfaces B: Biointerfaces, 160 (2017) 520-526.
29) I. Takeuchi, K. Nomura, K. Makino, “Hydrophobic boron compound-loaded poly(L-lactide-co-glycolide) nanoparticles for boron neutron capture therapy”, Colloids and Surfaces B: Biointerfaces, 159 (2017) 360 -365.
30) I. Takeuchi, T. Suzuki, K. Makino, “Skin permeability and transdermal delivery route of 50-nm indomethacin-loaded PLGA nanoparticles,” Colloids and Surfaces B: Biointerfaces, 159 (2017) 312-317.
31) I. Takeuchi, Y. Tetsuka, T. Nii, M. Shinogase, K. Makino, “Inhalable nanocomposite particles using amino acids with improved drug content and humidity resistance”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 529 ( 2017) 387-393.
32) I. Takeuchi, S. Yamaguchi, S. Goto, K. Makino, “Drug release behavior of hydrophobic drug-loaded poly(lactide-co-glycolide) nanoparticles: Effects of glass transition temperature”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 529 (2017) 328-333.
33) I. Takeuchi, S. Kobayashi, Y. Hida, K. Makino, “Estradiol-loaded PLGA nanoparticles for improving low bone mineral density of cancellous bone caused by osteoporosis: Application of enhanced charged nanoparticles with iontophoresis”, Colloids and Surfaces B. : Biointerfaces, 155 (2017) 35-40.
34) I. Takeuchi, Y. Ishizuka, H. Uchiro, K. Makino, “Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation”, Colloid and Polymer Science, 295 (2017) 1455-1461.
35) I. Takeuchi, K. Tomoda, M. Koji, K. Makino, “Hydrophilic drug-loaded PLGA nanoparticles for transdermal delivery”, Colloid and Polymer Science, 295 (2017) 977-983.
36) I. Takeuchi, K. Tomoda, A. Hamano, K. Makino, “Effects of physicochemical properties of poly(lactide-co-glycolide) on drug release behavior of hydrophobic drug-loaded nanoparticles”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 520 (2017) 771-778.
37) I. Takeuchi, S. Nobata, N. Oiri, K. Tomoda, K. Makino, “Biodistribution and excretion of colloidal gold nanoparticles after intravenous injection: Effects of particle size”, Bio-Medical Materials and Engineering, 28 (2017) ) 315-323.
38) I. Takeuchi, K. Fukuda, S. Kobayashi, K. Makino, “Transdermal delivery of estradiol-loaded PLGA nanoparticles using iontophoresis for treatment of osteoporosis”, Bio-Medical Materials and Engineering, 27 (2016) 475-483.
39) I. Takeuchi, K. Tomoda, K. Matsumoto, H. Uchiro, K. Makino, “PEGylated liposomes prepared with polyborane instead of cholesterol for BNCT: characteristics and biodistribution evaluation”, Colloid and Polymer Science, 294 (2016) 1679 -1685.
40) I. Takeuchi, K. Shimakura, H. Kuroda, T. Nakajima, S. Goto, K. Makino, “Estimation of crystallinity of nifedipine-polyvinylpyrrolidone solid dispersion by usage of terahertz time-domain spectroscopy and of X-ray powder diffractometer”, Journal of Pharmaceutical Sciences, 104 (2015) 4307-4313.
41) I. Takeuchi, K. Shimakura, K. Ohtake, J. Takayanagi, K. Tomoda, T. Nakajima, H. Terada, K. Makino, “Nondestructive analysis of structure and components of tablet coated with film by the usage of terahertz time-domain reflection spectroscopy”, Journal of Pharmaceutical Sciences, 103 (2014) 256-261.
42) I. Takeuchi, K. Tomoda, T. Nakajima, H. Terada, H. Kuroda, K. Makino, “Estimation of crystallinity of trehalose dihydrate microspheres by usage of terahertz time-domain spectroscopy”, Journal of Pharmaceutical Sciences, 101 (2012) 3465-3472.

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Social contribution activities

・Journal of the Japan Oil Chemistry Society, editorial committee of "Oleoscience"