Tetsuya Hasegawa

Main subjects

medical pharmacy, clinical pharmacokinetics

Research theme/keyword

・Study on in vitro metabolism and absorption by alternative methods for experimental animals ・Study on evaluation of quality and efficacy of functional ingredients

Final academic background/degree

Graduate Graduate School of Pharmaceutical Sciences Kumamoto University / Ph.D.

licence · Qualification

pharmacist

Affiliated academic society

The Pharmaceutical Society of Japan, The Pharmaceutical Society of Japan, The Japanese Pharmaceutical Association, The Japanese Society of Hospital Pharmacists

Major achievements

1. Matsumoto K., Hasegawa T., Ohara K., Kamei T., Koyanagi J., Akimoto M., Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. Xenobiotica 51, 155-166 (2021).
2. Matsumoto K., Hasegawa T., Ohara K., Takei C., Kamei T., Koyanagi J., Takahashi T., Akimoto M., A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy -2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. Xenobiotica 50, 783-792 (2020).
3. Matsumoto K., Hasegawa T., Ohara K., Takei C., Akimoto M., Roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone. J. Pharm. Investig., 50, 71-79 (2020).

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extracurricular activities

Member of Kanto Region Coordinating Organization for Hospital and Pharmacy Practical Training, Council of Pharmaceutical Education; Member of Acceptance Committee for Pharmacy Students, Chiba Prefectural Pharmaceutical Association; External Member of Research Ethics Review Committee, East Chiba Medical Center; Director, Academic Council of Holistic Science