Tomoyo Kamei

Main subjects

synthetic organic chemistry

Research theme/keyword

Research and development of absolute configuration determination reagents, natural product synthesis

Major achievements

1. T. Kamei, Y. Kimura, J. Koyanagi , K. Matsumoto, T. Hasegawa, M. Akimoto, T. Takahashi, Determination of the Absolute Configuration of the Nabumetone Metabolite 4-(6-Methoxy-2-naphthyl) butan-2-ol Using the Chiral Derivatizing Agent, 1-Fluoroindan-1-carboxylic acid. Chem. Pharm. Bull., 67(1), 75-785 (2019).
2. T. Kamei, T. Takahashi, H. Teramae, J. Koyanagi, Synthesis and Evaluation of FICA Derivatives as Chiral Derivatizing Agents. Chem. Pharm. Bull., 68(8), 818-8216 (2020).
3. K. Matsumoto, T. Hasegawa, K. Ohara, T. Kamei, J. Koyanagi, M. Akimoto, Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. Xenobiotica, 51, 155-166 (2021).

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