Tetsuya Hasegawa

Main subjects

Advanced medical pharmacy, medical pharmacy practice

Research Themes and Keywords

・ Research into in vitro metabolism and absorption using alternative methods to experimental animals ・ Research into the evaluation of the quality and effectiveness of functional ingredients

Final academic background/degree

Kumamoto University Graduate School of Graduate School of Pharmaceutical Sciences /PhD

licence · Qualification

pharmacist

Affiliated academic society

The Pharmaceutical Society of Japan, The Pharmaceutical Society of Japan, The Japanese Pharmaceutical Association, The Japanese Society of Hospital Pharmacists

Major achievements

1. Matsumoto K., Hasegawa T., Ohara K., Kamei T., Koyanagi J., Akimoto M., Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. Xenobiotica 51, 155-166 (2021).
2. Matsumoto K., Hasegawa T., Ohara K., Takei C., Kamei T., Koyanagi J., Takahashi T., Akimoto M., A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy -2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. 783-792 (2020).
3. Matsumoto K., Hasegawa T., Ohara K., Takei C., Akimoto M., Roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone. J. Pharm. Investig., 50, 71-79 (2020).
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extracurricular activities

Member of the Kanto Region Coordination Organization for Hospital and Pharmacy Practical Training of the Pharmaceutical Education Council, Member of the Chiba Prefecture Pharmacists Association Pharmacy Student Acceptance Committee, External Member of the Research Ethics Review Committee of Chiba Medical Center, Director of the Holistic Science Academic Council