Michiyoshi Nukaga

Main subjects

･Advanced Biopharmaceuticals ･Graduate School Special Lectures ･Graduate School Special Seminars

Research Themes and Keywords

薬剤耐性の分子機構

Final academic background/degree

千葉大学/博士（薬学）

Licenses/Qualifications

pharmacist

Affiliated academic society

日本薬学会、日本最近学会、アメリカ化学会

Major achievements

1. Mojica MF, Becka SA, Edwards M, Myers C, Uehara K, Uehara T, Hoshino T, Zeiser ET, Chatwin CL, Six DA, Bonomo RA, Papp-Wallace KM, Nukaga M. Burkholderia pseudomallei PenI β-lactamase and variants are potently inhibited by taniborbactam. Antimicrob Agents Chemother. 2025 Oct;69(10):e0078725. doi: 10.1128/aac.00787-25.
2. Kamo T, Kuroda K, Nimura S, Guo Y, Kondo S, Nukaga M, Hoshino T. Development of Inhibitory Compounds for Metallo-beta-lactamase through Computational Design and Crystallographic Analysis. Biochemistry. 2024 May 21;63(10):1278-1286. doi: 10.1021/acs.biochem.
3. Mojica MF, Nukaga M, Becka SA, Zeiser ET, Hoshino T, LiPuma JJ, Papp-Wallace KM. Frameshift Mutations in Genes Encoding PBP3 and PBP4 Trigger an Unusual, Extreme β-Lactam Resistance Phenotype in Burkholderia multivorans. ACS Infect Dis. 2024 Nov 8;10(11):3810-3820. doi: 10.1021/acsinfecdis.4c00330.


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