Kaori Matsumoto

Main subjects

Medical Pharmacy III, Clinical Pharmacokinetics, Introduction to Pharmacy A, Introduction to Pharmacy B, Medical Pharmacy Practical Training II, Hospital/Pharmacy Pre-learning, Hospital/Pharmacy Practical Training

Research theme/keyword

Elucidation of the significance of flavin-containing monooxygenase 5 as a human drug metabolizing enzyme

Final academic background/degree

Josai International University / Ph.D.

licence · Qualification

pharmacist

Affiliated academic society

Japanese Association of Hospital Pharmacists, Japan Pharmaceutical Association, Pharmaceutical Society of Japan, Pharmaceutical Society of Japan

Major achievements

1. Matsumoto K., Hasegawa T., Ohara K., Kamei T., Koyanagi J., Akimoto M., Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. Xenobiotica 51, 155-166 (2021).
2. Matsumoto K., Hasegawa T., Ohara K., Takei C., Kamei T., Koyanagi J., Takahashi T., Akimoto M., A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy -2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. Xenobiotica 50, 783-792 (2020).
3. Matsumoto K., Hasegawa T., Ohara K., Takei C., Akimoto M., Roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone. J. Pharm. Investig., 50, 71-79 (2020).

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