JIU Josai International University
MATSUMOTO Kaori
Associate Professor
area of expertise: medical pharmacy
Main subjects
Medical Pharmacology C, Clinical Pharmacokinetics, Introduction to Pharmacy A, Introduction to Pharmacy B, Medical Pharmacy Training B, Preparatory Study for Hospitals and Pharmacies, Practical Training for Hospitals and Pharmacies
Research Themes and Keywords
Elucidation of the significance of flavin-containing monooxygenase 5 as a human drug metabolizing enzyme
Final academic background/degree
Josai International University / Ph.D.
licence · Qualification
pharmacist
Affiliated academic society
Japanese Association of Hospital Pharmacists, Japan Pharmaceutical Association, Pharmaceutical Society of Japan, Pharmaceutical Society of Japan
Major achievements
1. Matsumoto K., Hasegawa T., Ohara K., Kamei T., Koyanagi J., Akimoto M., Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. Xenobiotica 51, 155-166 (2021).
2. Matsumoto K., Hasegawa T., Ohara K., Takei C., Kamei T., Koyanagi J., Takahashi T., Akimoto M., A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy -2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. 783-792 (2020).
3. Matsumoto K., Hasegawa T., Ohara K., Takei C., Akimoto M., Roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone. J. Pharm. Investig., 50, 71-79 (2020).
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